Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. To acquire additional. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. It appears mostly in young patients and females, the maxillary.

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Adenomatoid odontogenic tumor AOTa benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade. Carmo and Silva 2 tried to correlate its clinical behavior with the cell proliferation rate assessed by AgNOR histochemistry.

They are treated conservatively by curettage and enucleation as both are benign in nature.

Dentigerous cyst, unicystic ameloblastoma, ameloblastoma, and ameloblastic fibroma are most frequent in the posterior region aeenomatoid the mandible and are associated in most cases with the third molar. The immunohistochemical analysis showed positive results for laminin in the luminal surface of the cells bordering the adenomatoid structures, in the small intercellular deposits of lighter eosinophilic material interspersed in the epithelial proliferation of spindled areas and cords, and on the borders between the tumor and connective tissue Figure 3.

Teeth examination revealed that teeth 22 and 23 are missing, and teeth 21 and 24 are positive at cold sensitivity test without mobility. The hamartomatous lesion would start at the REE and occasionally would not hinder dental eruption. The results for CK7, 18, vimentin, and p53 were negative. It is usually associated with an impacted canine. Abstract Adenomatoid odontogenic tumor Odonrogenica benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade.

The large adenomatoid structures, resulting from the circular tridimensional, “tubular” configuration of the columnar tumlr and cylindrical superficial cells of the REE due to its hamartomatous growth, would be formed in recent tumors, right from their onset.

This may give support to discussions about the existing hypothesis for tumor pathogenesis and biological nature. It should be emphasized that although AOT is very rare, careful diagnosis and adequate interpretation of clinical and radiographic findings may be helpful in arriving at a correct diagnosis.


Introduction Adenomatod in was the first to describe adenomatoid odontogenic tumor AOTwhich is an uncommon benign epithelial lesion of odontogenic origin known as a pseudo-adenoameloblastoma [ 1 ].

Histological typing of odontogenic tumors, jaw cysts, and allied lesions.

Case Reports in Dentistry

We believe that AOT cells might be able to secrete two types of substances, according to adenomatooid functional capability: Eur J Radiol ;1: Immunohistochemical demonstration of an enamel sheath protein, sheatlin, in odontogenic tumors. It is known fact that odontogenic cysts can be associated with odontogenic tumors. Adenomatoid odontogenic cyst, adenomatoid odontogenic tumor, hamartoma.

On extraoral examination Figure 2 afacial asymmetry was noted. A solitary well-defined swelling on the left side of the face in the region of the nasal ala was palpable. But in our case presented, the presence of unilocular cystic lesion, fluid on aspiration, and cystic cavity on transection has to some extent support the terminology adenomatoid odontogenic cyst AOC as termed by Marx and Stern. The issue of its nature being neoplastic or hamartomatous is still object of diverging opinions, generally based on clinical observations and little scientific evidence.

Discussion AOT usually occurs within the tooth bearing areas of jaws and often found in association with impacted teeth.

The conflicting views whether the lesion is being neoplasm or an anomalous hamartomatous growth is oeontogenic being discussed. AOT occurs mainly in the second decade of life, and is uncommon in patients older than 30 years of age.

AOT usually occurs within the tooth bearing areas of jaws and often found in association with impacted teeth. Int J Oral Maxillofac Pathol.

Adenomatoid odontogenic tumor, an uncommon tumor

The extraction of the impacted left maxillary canine was recommended due to its buccal position and absence of the vestibular cortical bone as shown on a Cone Beam Computerized Tomography CBCT Figure 1.

Singapore Med J ; In stafne reported first series of AOT under the title epithelial tumors associated with developments cyst of maxilla.

Histological typing of odontogenic odontogfnic, jaw cysts, and allied lesions. The control orthopantomogram on the third month Figure 7 followed by other on six months later showed normal bone trabeculation at the lesion site without recurrence. Corroborating this idea is the known influence of the REE on the modifications in the composition of enamel after amelogenesis, in normal conditions, which does not play only the protective role Ten Cate 23 Few cases of AOT, like this case, were described in the literature in association with a maxillary lateral incisor.


AOT affects young individuals with a female predominance, occurs mainly in the second decade, and usually surrounds the crown of unerupted teeth. Oral and Tmuor Pathology. In this case, a year-old female presented with a well-demarcated radiolucent lesion of 2. Bull Tokyo Dent Coll ; In addition, the use of lyophilized bone and guided tissue regeneration are recommended in large osseous cavities.

The debate as to whether AOT is an anomalous hamartomatous growth or a true benign neoplasm has not been settled yet. The evolution of this tumor was followed over 36 months and 24 months after excision. Services on Demand Journal. Gross and histological examination of 45 cases.

Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation

How to cite this article. The continuous slow growth of the lesion may cause cortical plate expansion leading to a painless hard swelling, asymmetry of the face, and displacement of the teeth, as was evident in our case analysis. Interspersed in the solid areas, as if separating them in blocks, there were fusiform and stellated cells resembling the stellate reticulum with thin strands.

Report of two cases and survey of cases in Japan. For Takahashi, et al. A retrospective study of cases in a Chinese population.

PCNA results in the REE were as expected, with expression restrict to the basal or suprabasal cells or cells scattered in areas in which subepithelial inflammation was present.

Shafer’s Text book of Oral Pathology. Orthopantomogram after 1-year of stage two surgery Click here to view. Salvage of an impacted canine with an adenomatoid odontogenic tumour: Females are affected about twice as often as males [ 36 adenomatoiid, 8 ].